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Methadone belongs to a collection of drugs known as opioid. However it is used to treat pain that requires round the clock relief for long periods. Do not use this medication to treat pain that comes just once in a while. Together with medical supervision methadone has been found to treat opioid addiction caused by drugs such as heroin or morphine. Opioid relieve pains by reducing the way the brain responds to pain.


This medication should be taken as instructed by the doctor. Do not take too much or for a much longer period than prescribed. And if you want to stop please inform your doctor so he slowly lowers your doses to reduce chances of withdrawal symptoms.

Methadone tablets should be swallowed whole and not crushed, broken down, chewed, or dissolved.


There is no specific dose for every patient on methadone. So, your best bet is to follow your doctor’s prescription or the directions on the label. Below is the list of the average doses. The amount of medecine a patient takes depends on its strength, the number of doses, the frequecy with which you take it to name a few.

  • For oral dosage form (tablets):
    • For pain:
      • For patients taking Dolophine as the first pain medicine:
        • Adults—At first, 2.5 milligrams (mg) every 8 to 12 hours. Your doctor may adjust your dose as needed. Do not take more than your prescribed dose in 24 hours.
        • Children—Use and dose must be determined by your doctor.
      • For patients switching from other opioids to Dolophine:
        • Adults—The dose must be determined by your doctor based on the previous dose of opioid medicine. The dose is given every 8 or 12 hours. Your doctor may adjust your dose as needed. Do not take more than your prescribed dose in 24 hours.
        • Children—Use and dose must be determined by your doctor.
    • For opioid addiction:
      • Adults—At first, 20 to 30 milligrams (mg) taken as a single dose per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg per day. Do not take more than your prescribed dose in 24 hours.
      • Children—Use and dose must be determined by your doctor.


Methadone should be stored in a properly sealed container at room temperature, away from moisture, heat and direct light. Also keep out of the reach of children and ask your doctor how to properly dispose of unused drugs.

Methadone can have serious side effects when taken by adults who are not used to narcotic pain medicines. Make sure to store in a safe place to prevent others from getting it.


It is always wise that before using methadone, the patient and the doctor have a meeting to determine if the good out ways the bad before deciding on using this drug.


It is very important that you update your doctor on the effects of this drug regularly. This will allow your doctor to access if it is working well and whether to let you continue taking it.

Do not use this medicine if you are using or have used an MAO inhibitor within the past 14 days.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. Hence, it is not advised to take this medication with alcohol for risk of side effects such as drowsiness, blurred vision to name a few.

This medicine may be addictive (causing mental or physical dependence). If you feel the medicine is not working well. Please do not self prescribe but rather consult your doctor.

Using narcotics such as methadone for a long time can lead to severe constipation. To prevent this, it is normal for your doctor to direct you on the laxative and kind of foods to take( fiber rich foods). Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Also methadone might affect the results of some medical tests, so inform your doctor before carrying out any test.

This medication is not advisable for pregnant women as it may lead to some unwanted side effects in the new born. Side effects might include, abnormal sleep pattern, diarrhea, irritability, shakiness or tremors, weight loss to name a few.

Studies have shown that people on this medication for too long can become infertile. Talk to your doctor before using this medicine if you plan to have children.

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